Total PSA Test Price in Old Town Bhubaneswar

Test Description

Total Prostate-Specific Antigen (tPSA) measures all forms of PSA circulating in the blood — both free PSA (unbound, fPSA) and complexed PSA (bound to alpha-1-antichymotrypsin, ACT, and alpha-2-macroglobulin). Total PSA is the standard first-line test for prostate cancer screening, staging, and post-treatment surveillance. PSA is a serine protease produced by prostatic epithelial cells; while organ-specific, it is not cancer-specific and is elevated in benign prostatic hyperplasia (BPH), prostatitis, and after prostate instrumentation. Age-specific normal ranges apply; the traditional cutoff of 4.0 ng/mL is less accurate across age groups. Total PSA is used as part of the prostate cancer risk assessment algorithm alongside digital rectal examination (DRE), prostate volume assessment (PSA density), and multiparametric MRI (mpMRI) of the prostate. PSA velocity (>0.75 ng/mL/year increase) raises suspicion even within the normal range. Following radical prostatectomy, undetectable PSA (<0.1 ng/mL) defines biochemical remission; PSA nadir followed by confirmed rise defines biochemical recurrence. Following radiation therapy, the Phoenix criteria (PSA nadir + 2 ng/mL) define biochemical failure. In metastatic castration-resistant prostate cancer (mCRPC), serial PSA monitoring guides systemic therapy decisions.